The second pharmacology comment is about a PK parameter called the fluctuation ratio, which is to what — how high is C-max compared to C-min? In other words, at the peak of drug concentration, what is that compared to the trough before the next dose? If you space doses out through a very long time you get a higher fluctuation ratio. And the fluctuation ratio that we saw is around about twofold, which is quite small, or less, in the healthy subjects dosed once a day. http://benjaminmorganwire.denaliinstitute.org/2016/08/06/further-advice-on-quick-methods-for-selection-process/So on that basis, there’s no reason to give the drug more frequently. ——————————————————————————– Tazeen Ahmad, Bank of America – Analyst  ——————————————————————————– Okay. And then as far as the number of sites, I’m sorry if I missed it; how many sites are you using for APeX? ——————————————————————————– Bill Sheridan, BioCryst Pharmaceuticals, Inc. – SVP and Chief Medical Officer  ——————————————————————————– I didn’t say, so we’re going to enough sites to get the study done in the time frame that we need, and it will be in several European countries plus Canada. So it will be in quite a few more sites than we had in our OPuS-1 study, which was very restrictive. That was only, like, three or four sites in Germany and one in the UK.
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